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Edition 2018

Target Of Rapamycin
science club in France

22-23 May 2018
Saint Paul Hotel, Nice, France


photo Canaud
Guillaume Canaud
Necker Institute, Paris, France
photo Hall
Mike Hall
Biozentrum Basel, Switzerland
photo Leopold
Pierre Leopold
Curie Institute, Paris, France
photo Manning
Brendan Manning
Harvard University, USA


Best oral presentation


Best poster presentation


Best questions



22 May 2018

12:00 - 13:50
Arrival and check-in
13:50 - 14:00
Meeting opening remarks (Mario Pende)
Session 1: Signal Transduction and Pharmacology (Chair: Raul V. Durán)
14:00 – 14:45
Keynote lecture: Michael N. Hall
mTOR signaling in growth and metabolism
Biozentrum, University of Basel, Switzerland
14:55 – 15:05
Svetlana Dokudovskaya
SEA you later alli-GATOR – a dynamic regulator of the TORC1 pathway in yeast
Paris, France
14:55 – 15:05
Julien Averous
GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism
Clermont-Ferrand, France
15:05 – 15:15
Bojana Stefanovska
A new mTOR-independent effect of rapamycin: transcriptional regulation of TRIB3
Paris, France
15:15 – 15:25
Marie-Julie Nokin
A novel mechanism of mTOR inhibition displacing phosphatidic acid induces enhanced cytotoxicity specifically in cancer cells
Bordeaux, France
15:25 – 15:35
Martina Bonucci
Identification of growth signals causing kidney cyst formation by selectively controlling the orientation but not the rate of cell division
Paris, France
15:35 – 15:45
Raul V. Duran
Glutamoptosis: a mTORC1-dependent cell death mechanism during nutritional imbalance
Bordeaux, France
15:55 – 16:15
Coffee break
Session 2: Diseases (Chair: Stéphanie Baulac)
16:15 – 17:00
Keynote lecture: Guillaume Canaud
PIK3CA-Related Overgrowth Spectrum
Institut Necker Enfants Malades, Paris Descartes University, France
17:00 – 17:10
Daniela Cota
mTORC1 signaling orchestrates bidirectional control of food intake by hypothalamic POMC neurons
Bordeaux, France
17:10 – 17:20
Natacha Entz-Werle
Inhibition of mTor associated with HIF1 inhibitor in children with a refractory cancer: good tolerance and promising results in brain
Strasbourg, France
17:20 – 17:30
Emmanuelle Logette
mTOR in the Tuberous Sclerosis Complex (TSC): the patient’s side
Hindisheim, France
17:30 – 17:40
Talha Rashid
Lipin 1 deficiency in skeletal muscle causes sarcoplasmic reticulum stress and a mitochondrial myopathy responsive to fibrates and chaperons
Paris, France
17:40 – 17:50
Karine Dumas
REDD1 deficiency protects from high fat diet induced metabolic diseases
Nice, France
17:50 – 18:00
Jozef Bossowski
Low protein diet induces IRE1alpha-dependent anticancer immunosurveillance
Nice, France
18:00 – 18:10
Theo Ribierre
Somatic mosaic inactivation of Depdc5 in the developing mouse brain cortex causes epilepsy and focal cortical dysplasia
Paris, France
18:10 – 18:20
Stéphane Pyronnet
Is the mTORC1 substrate 4E-BP1 a therapeutic target for pancreatic cancer
Toulouse, France
18:20 – 18:30
Stéphanie Baulac
GATOR1/mTORC1 encoding genes: major culprits in focal epilepsies
Paris, France
18:30 – 20:00
Poster session
20:00 – Night
Networking activities

23 May 2018

8:00 - 9:30
Breakfast and check-out
Session 3 - Genetic models (Chair: Svetlana Dokudovskaya)
9:30 – 10:15
Keynote lecture: Pierre Leopold
Orchestrating the nutrient response during Drosophila development
Institute of Biology Valrose, Nice, France
10:15 – 10:25
Christian Meyer
The plant TOR signalling pathway
Paris, France
10:25 – 10:35
Benoit Menand
Discovery of new components of the plant TOR signaling pathway using a pharmaco-genetic approach
Marseille, France
10:35 – 10:45
Mikhail Schepetilnikov
Mechanism of TOR activation by Rho-like plant GTPase ROP2
Strasbourg, France
10:45 – 10:55
Roberta Rapone
Unusual cytoplasmic role of the “histone” lysine methytransferase SETDB1
Paris, France
10:45 – 10:55
Jacques Montagne
Nutrient activation of S6Kinase provides competence for starvation-induced autophagy
Gif-sur-Yvette, France
11:05 – 11:30
Coffee break
Session 4 - Output targets (Chair: Mario Pende)
11:30 – 12:15
Keynote lecture: Brendan Manning
The mTOR network: signal integration and metabolic regulation
Harvard T. H. Chan School of Public Health, Boston, US
12:15 – 12:25
Mickaël Ohanna
Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype
Nice, France
12:25 – 12:35
Jing Li
Patterns of drug selection reveal shared molecular targets over short and long evolutionary timescales
Nice, France
12:35 – 12:45
Yinxing Ma
Tumor suppressor NPRL2 from GATOR1 complex induces ROS production and DNA damage response
Paris, France
12:45 – 12:55
Ning Liang
YAP and TEAD4 regulate transcription and respiration in mitochondria
Paris, France
12:55 – 13:05
Antoine Marçais
High mTOR activity is a hallmark of reactive Natural Killer cells and amplifies early signaling through activating receptors
Lyon, France
13:05 – 13:30
Concluding remarks and awards
13:05 – 15:00
Lunch + Networking activities

Scientific Committee

photo Baulac
Stéphanie Baulac
ICM, Paris, France
photo Cota
Daniela Cota
Magendie Inst., Bordeaux, France
photo Dokudovskaya
Svetlana Dokudovskaya
IGR, Villejuif, France
photo Duran
Raul Duran
IECB, Bordeaux, France
photo Fafournoux
Pierre Fafournoux
INRA, Clermont Ferrand, France
photo Gangloff
Yann Gaël Gangloff
INMG, Lyon, France
photo Italiano
Antoine Italiano
photo Meyer
Christian Meyer
Bourgin Inst., Paris, France
photo Montagne
Jacques Montagne
I2BC, Gif-sur-Yvette, France
photo Pende
Mario Pende
Necker Inst., Paris, France
photo Pyronnet
Stéphane Pyronnet
CRCT, Toulouse, France
photo Ricci
Jean Ehrland Ricci
C3M, Nice, France
photo Ryabova
Lyuba Ryabova
Strasbourg Univ., France
photo Seiliez
Iban Seiliez
INRA, Saint P
photo Tamburini
Jérôme Tamburini
Cochin Inst., Paris, France