Target of Rapamycin
science club in France

- 1st edition -

22-23 May 2018
Saint Paul Hotel, Nice, France

About the Workshop

Target Of Rapamycin (TOR) signal transduction has an evolutionary conserved role in the control of growth, metabolism and ageing depending on nutrient availability. We aim at promoting a Science Club on TOR signal transduction in France, "le TOR de France". The goal is to gather students, postdocs, group leaders working in the field of TOR, nutrition, growth, development with approaches of cellular and molecular biology, genetics, evolution and the applications in medicine, pharmacology, human health.

The first edition of the TOR de France meeting will cover multiple areas of investigation including:

  • Molecular mechanisms of cell growth control across species
  • Genetic alterations of TOR signal transduction in human diseases
  • Link between caloric restriction and ageing
  • Therapeutic strategies to inhibit TOR signal transduction in cancer and metabolic syndromes

The scientific committee comprises 17 recognized scientists working in French Academic Institutions and Hospitals. International leaders, such as Brendan Manning (Harvard Medical School, US) and the 2017 Lasker award Mike Hall (Basel Biozentrum, Switzerland), will present keynote lectures at the meeting.

The registration is free but required!

Registration Deadline
30 March 2018
Abstract Submission Deadline
30 March 2018

Registration now closed!


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Guillaume Canaud
Necker Institute, Paris
Mike Hall
Biozentrum Basel, Switzerland
Pierre Leopold
Curie Institute, Paris
Brendan Manning
Harvard University, USA


22 May 2018

12:00 - 13:50
Arrival and check-in
13:50 - 14:00
Meeting opening remarks (Mario Pende)
Session 1: Signal Transduction and Pharmacology (Chair: Raul V. Durán)
14:00 – 14:45
Keynote lecture: Michael N. Hall
mTOR signaling in growth and metabolism
Biozentrum, University of Basel, Switzerland
14:55 – 15:05
Svetlana Dokudovskaya
SEA you later alli-GATOR – a dynamic regulator of the TORC1 pathway in yeast
Paris, France
14:55 – 15:05
Julien Averous
GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism
Clermont-Ferrand, France
15:05 – 15:15
Bojana Stefanovska
A new mTOR-independent effect of rapamycin: transcriptional regulation of TRIB3
Paris, France
15:15 – 15:25
Marie-Julie Nokin
A novel mechanism of mTOR inhibition displacing phosphatidic acid induces enhanced cytotoxicity specifically in cancer cells
Bordeaux, France
15:25 – 15:35
Martina Bonucci
Identification of growth signals causing kidney cyst formation by selectively controlling the orientation but not the rate of cell division
Paris, France
15:35 – 15:45
Raul V. Duran
Glutamoptosis: a mTORC1-dependent cell death mechanism during nutritional imbalance
Bordeaux, France
15:55 – 16:15
Coffee break
Session 2: Diseases (Chair: Stéphanie Baulac)
16:15 – 17:00
Keynote lecture: Guillaume Canaud
PIK3CA-Related Overgrowth Spectrum
Institut Necker Enfants Malades, Paris Descartes University, France
17:00 – 17:10
Daniela Cota
mTORC1 signaling orchestrates bidirectional control of food intake by hypothalamic POMC neurons
Bordeaux, France
17:10 – 17:20
Natacha Entz-Werle
Inhibition of mTor associated with HIF1 inhibitor in children with a refractory cancer: good tolerance and promising results in brain
Strasbourg, France
17:20 – 17:30
Emmanuelle Logette
mTOR in the Tuberous Sclerosis Complex (TSC): the patient’s side
Hindisheim, France
17:30 – 17:40
Talha Rashid
Lipin 1 deficiency in skeletal muscle causes sarcoplasmic reticulum stress and a mitochondrial myopathy responsive to fibrates and chaperons
Paris, France
17:40 – 17:50
Karine Dumas
REDD1 deficiency protects from high fat diet induced metabolic diseases
Nice, France
17:50 – 18:00
Jozef Bossowski
Low protein diet induces IRE1alpha-dependent anticancer immunosurveillance
Nice, France
18:00 – 18:10
Theo Ribierre
Somatic mosaic inactivation of Depdc5 in the developing mouse brain cortex causes epilepsy and focal cortical dysplasia
Paris, France
18:10 – 18:20
Stéphane Pyronnet
Is the mTORC1 substrate 4E-BP1 a therapeutic target for pancreatic cancer
Toulouse, France
18:20 – 18:30
Stéphanie Baulac
GATOR1/mTORC1 encoding genes: major culprits in focal epilepsies
Paris, France
18:30 – 20:00
Poster session
20:00 – Night
Networking activities

23 May 2018

8:00 - 9:30
Breakfast and check-out
Session 3 - Genetic models (Chair: Svetlana Dokudovskaya)
9:30 – 10:15
Keynote lecture: Pierre Leopold
Orchestrating the nutrient response during Drosophila development
Institute of Biology Valrose, Nice, France
10:15 – 10:25
Christian Meyer
The plant TOR signalling pathway
Paris, France
10:25 – 10:35
Benoit Menand
Discovery of new components of the plant TOR signaling pathway using a pharmaco-genetic approach
Marseille, France
10:35 – 10:45
Mikhail Schepetilnikov
Mechanism of TOR activation by Rho-like plant GTPase ROP2
Strasbourg, France
10:45 – 10:55
Roberta Rapone
Unusual cytoplasmic role of the “histone” lysine methytransferase SETDB1
Paris, France
10:45 – 10:55
Jacques Montagne
Nutrient activation of S6Kinase provides competence for starvation-induced autophagy
Gif-sur-Yvette, France
11:05 – 11:30
Coffee break
Session 4 - Output targets (Chair: Mario Pende)
11:30 – 12:15
Keynote lecture: Brendan Manning
The mTOR network: signal integration and metabolic regulation
Harvard T. H. Chan School of Public Health, Boston, US
12:15 – 12:25
Mickaël Ohanna
Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype
Nice, France
12:25 – 12:35
Jing Li
Patterns of drug selection reveal shared molecular targets over short and long evolutionary timescales
Nice, France
12:35 – 12:45
Yinxing Ma
Tumor suppressor NPRL2 from GATOR1 complex induces ROS production and DNA damage response
Paris, France
12:45 – 12:55
Ning Liang
YAP and TEAD4 regulate transcription and respiration in mitochondria
Paris, France
12:55 – 13:05
Antoine Marçais
High mTOR activity is a hallmark of reactive Natural Killer cells and amplifies early signaling through activating receptors
Lyon, France
13:05 – 13:30
Concluding remarks and awards
13:05 – 15:00
Lunch + Networking activities

Abstract and presentation guidelines

Abstracts will be selected for short oral or poster presentations.
Short talk and poster prizes for postdocs and students will be awarded.

Abstract specifications

  • Title: 20 words maximum in english
  • Authors: full names and affiliations (in brackets)
  • Text: 250 words maximum in english

Short talk specifications

  • 10min oral presentation in english

Poster specifications

  • Poster format: A0
  • Width: 90 cm
  • Height: 120 cm

Scientific Committee

Stéphanie Baulac
ICM, Paris
Daniela Cota
Magendie Inst., Bordeaux
Svetlana Dokudovskaya
IGR, Villejuif
Raul Duran
IECB, Bordeaux
Pierre Fafournoux
INRA, Clermont Ferrand
Yann Gaël Gangloff
INMG, Lyon
Antoine Italiano
Bergonié Inst., Bordeaux
Christian Meyer
Bourgin Inst., Paris
Jacques Montagne
I2BC, Gif-sur-Yvette
Mario Pende
Necker Inst., Paris
Stéphane Pyronnet
CRCT, Toulouse
Jean Ehrland Ricci
C3M, Nice
Lyuba Ryabova
Strasbourg Univ.
Iban Seiliez
INRA, Saint Pée sur Nivelle
Jérôme Tamburini
Cochin Inst., Paris


Le Saint Paul Hotel

29 boulevard Franck Pilatte 06300 Nice

France - Europe

+33 (0)4 93 89 39 57

Meals and Accomodation

The meals that are mentioned in the program are free of charge for the participants. The participants should find suitable accommodations and book them at their own expenses. Convenient locations for the close proximity may be the following:

Le Saint Paul Hotel Indicate the name of the meeting "TOR de France" when you book the hotel
Hôtel Ibis Styles Nice Vieux Port Indicate the name "TOR" to get an offer for the rooms

Contact us